PEPCID (Injectable)

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6. PEPCID (Injectable)

Overview / Definition

PEPCID (famotidine) injectable is an H2 receptor antagonist used to reduce stomach acid secretion in patients with gastroesophageal reflux disease (GERD), Zollinger-Ellison syndrome, and for prevention of stress ulcers in critically ill patients.

Causes or Mechanism

Famotidine blocks histamine H2 receptors on gastric parietal cells, decreasing acid production and promoting healing of ulcers and esophageal inflammation.

Signs & Symptoms (Indications)

  • GERD symptoms relief
  • Prevention and treatment of gastric and duodenal ulcers
  • Zollinger-Ellison syndrome management
  • Prevention of stress ulcers in ICU patients

Diagnosis

Clinical diagnosis of acid-related disorders or prophylaxis in high-risk patients.

Treatment / Management

  • Administered IV or IM as per dosage guidelines.
  • Dose adjusted for renal impairment.
  • Monitor acid suppression and symptom resolution.

Side Effects

  • Headache, dizziness
  • Diarrhea or constipation
  • Rare hypersensitivity reactions
  • Possible thrombocytopenia with prolonged use

Warnings and Precautions

  • Use with caution in renal impairment
  • Monitor for CNS effects in elderly
  • Avoid abrupt discontinuation in ulcer treatment

Drug Interactions

Minimal; caution with drugs requiring acidic environment for absorption.

FAQs

  1. How fast does PEPCID work?
    Within 1 hour after injection.
  2. Can it be given orally?
    Yes, oral forms are available.
  3. Is it safe in pregnancy?
    Category B, consult doctor.
  4. What if I miss a dose?
    Take as soon as possible, do not double dose.
  5. Can it cause allergic reactions?
    Rare but possible; seek immediate care.

References

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