ESCLIM (Transdermal)

By /

ESCLIM (Transdermal) – Comprehensive Medical Article

Uses & Indications

ESCLIM is a transdermal estradiol patch indicated for:

  • Relief of moderate to severe vasomotor symptoms of menopause such as hot flashes and night sweats.
  • Prevention of osteoporosis in postmenopausal women at increased risk of fractures.
  • Management of hypoestrogenism due to ovarian failure or surgical menopause.

ESCLIM is designed for women requiring systemic estrogen therapy, especially those who benefit from non-oral administration.

How It Works

ESCLIM delivers bioidentical estradiol transdermally, providing a steady release of hormone directly into systemic circulation while bypassing the liver’s first-pass metabolism.

Estradiol acts by:

  • Binding estrogen receptors in the hypothalamus to reduce vasomotor instability.
  • Maintaining bone density by inhibiting osteoclastic activity.
  • Restoring urogenital tissue structure and function.

Transdermal delivery reduces the risk of venous thromboembolism compared to oral estrogens.

Dosage and Administration

  • The patch is typically applied twice weekly to clean, dry, intact skin on the lower abdomen or buttocks.
  • Dosing strength varies; common doses range from 0.05 mg to 0.1 mg estradiol per day.
  • Rotate application sites to prevent skin irritation.
  • Do not apply on breasts or irritated skin.
  • If a patch detaches, replace it immediately.

Side Effects

Common side effects include:

  • Local skin irritation.
  • Breast tenderness.
  • Headache.
  • Nausea.
  • Abdominal cramps.
  • Bloating.

Serious adverse effects (rare):

  • Venous thromboembolism.
  • Stroke.
  • Myocardial infarction.
  • Increased risk of estrogen-dependent cancers.
  • Gallbladder disease.

Warnings and Precautions

  • Contraindicated in women with breast cancer, undiagnosed vaginal bleeding, active thromboembolism, liver disease, or known hypersensitivity.
  • Women with a uterus should use a progestin concomitantly to reduce endometrial cancer risk.
  • Caution in women with cardiovascular risk factors.
  • Monitor blood pressure and perform regular cancer screening.

Drug Interactions

  • CYP3A4 inducers (e.g., carbamazepine, phenytoin) may reduce estradiol levels.
  • CYP3A4 inhibitors (e.g., ketoconazole) may increase estradiol concentration.
  • Estrogens may alter metabolism of thyroid hormone, anticoagulants, and antidiabetic drugs.

FAQs

Q: How long can I use ESCLIM safely?
A: Use the lowest effective dose for the shortest duration to control symptoms; reassess therapy annually.

Q: Can ESCLIM cause weight gain?
A: Some patients report fluid retention and mild weight gain, but evidence is variable.

Q: What should I do if I experience abnormal bleeding?
A: Consult your healthcare provider promptly for evaluation.

References

  1. ESCLIM FDA Label – https://www.pmda.go.jp/PmdaSearch/iyakuDetail/GeneralList/5600699A1021
  2. Mayo Clinic – Menopause and Hormone Therapy – https://www.mayoclinic.org/tests-procedures/hormone-therapy/about
  3. MedlinePlus – Estradiol Patch – https://medlineplus.gov/druginfo/meds/a601041.html

Table of Contents

→ Index
Scroll to Top