fempatch-transdermal
Uses & Indications
Fempatch-transdermal is a hormone replacement therapy (HRT) patch delivering estradiol for relief of moderate to severe vasomotor symptoms of menopause such as hot flashes and night sweats. It is also indicated for prevention of osteoporosis in postmenopausal women at risk of fractures. It is prescribed for women experiencing hypoestrogenism due to menopause or ovarian failure.
How It Works
Fempatch-transdermal releases bioidentical estradiol through the skin directly into systemic circulation, bypassing first-pass liver metabolism. Estradiol binds to estrogen receptors in target tissues, including the hypothalamus to regulate thermoregulation, bones to maintain density by inhibiting osteoclasts, and vaginal mucosa to restore elasticity and lubrication.
Dosage and Administration
Apply one patch to clean, dry, intact skin (typically lower abdomen or buttocks) once or twice weekly depending on prescribed dose. Rotate application sites to prevent skin irritation. Avoid application on breasts or broken skin. If a patch detaches prematurely, replace it immediately.
Side Effects
Common side effects include skin irritation at application site, breast tenderness, headache, nausea, bloating, and spotting. Rare serious effects include thromboembolism, stroke, myocardial infarction, and estrogen-dependent cancers.
Warnings and Precautions
Contraindicated in women with undiagnosed vaginal bleeding, known or suspected breast or endometrial cancer, active thromboembolic disease, liver impairment, or pregnancy. Women with an intact uterus should receive concomitant progestin to reduce risk of endometrial hyperplasia. Use with caution in patients with cardiovascular disease risk factors.
Drug Interactions
Inducers of CYP3A4 (e.g., rifampin, carbamazepine) may reduce estradiol levels. Inhibitors (e.g., ketoconazole) may increase estradiol exposure. Estrogens may affect anticoagulants, thyroid hormones, and antidiabetics.
FAQs
Q: Can I swim or shower with the Fempatch on?
A: Yes, but avoid prolonged soaking.
Q: How soon will I notice symptom relief?
A: Improvement typically occurs within 1-2 weeks.
Q: Do I need to add progestin?
A: Yes, if you have a uterus to reduce cancer risk.
References
- FDA Estradiol Patch Label – https://www.accessdata.fda.gov/drugsatfda_docs/label/
- Mayo Clinic – Hormone Replacement Therapy – https://www.mayoclinic.org/tests-procedures/hormone-therapy/about
- MedlinePlus – Estradiol Patch – https://medlineplus.gov/druginfo/meds/a601041.html
