Drug Information
| Brand name Or ID | HYDROCORTONE 806527 |
| Full generic name | Hydrocortisone 25 MG/ML Injectable Suspension |
| Drug display name | HYDROCORTONE (Injectable) |
| Dose form | Injectable Suspension |
| Drug concentration | 25 mg/ml |
| Route of administration | Injectable |
| Pregnancy category | |
| Alternatives |
Hydrocortisone (Injectable): Comprehensive Medical Guide
Introduction
Hydrocortisone injectable is a corticosteroid medication used to treat various inflammatory and autoimmune conditions, as well as hormone replacement in adrenal insufficiency. Delivered via injection, hydrocortisone offers rapid and effective control of inflammation, allergic reactions, and immune system dysregulation. This guide provides a detailed overview of hydrocortisone injectable, covering its uses, mechanism, dosage, side effects, precautions, interactions, and frequently asked questions, tailored for healthcare professionals and informed patients.
Uses & Indications
Hydrocortisone injectable is commonly used for:
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Adrenal Insufficiency: Acute or chronic cortisol replacement in Addison’s disease or adrenal crisis.
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Severe Allergic Reactions: Including anaphylaxis adjunct therapy.
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Inflammatory Disorders: Such as rheumatoid arthritis, lupus, and severe asthma exacerbations.
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Shock States: Particularly septic shock as part of supportive therapy.
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Dermatologic and Ophthalmic Conditions: Severe inflammations unresponsive to topical treatment.
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Other Indications: Certain cancers, autoimmune diseases, and hematologic disorders.
How It Works
Hydrocortisone is a synthetic glucocorticoid mimicking natural cortisol. It:
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Suppresses inflammation by inhibiting inflammatory mediators (prostaglandins, cytokines).
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Modulates immune response to prevent tissue damage.
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Affects carbohydrate, protein, and fat metabolism to support the body under stress.
Dosage and Administration
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Dosage: Varies by indication; typical acute doses range from 100 mg to 500 mg daily.
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Routes: Intravenous (IV) for rapid effect; intramuscular (IM) when IV access is unavailable.
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Frequency: Usually every 6-12 hours depending on clinical need.
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Administration: Performed by trained medical personnel under sterile conditions.
Side Effects
Possible side effects include:
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Injection site pain or irritation.
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Elevated blood sugar, especially in diabetics.
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Fluid retention, hypertension.
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Mood changes (anxiety, mood swings).
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Increased infection risk.
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Long-term use risks: osteoporosis, adrenal suppression.
Warnings and Precautions
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Use cautiously in infections, diabetes, hypertension, osteoporosis.
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Monitor blood glucose and blood pressure during treatment.
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Avoid sudden discontinuation after prolonged use.
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Use with caution in pregnancy and lactation.
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Inform your doctor of all medications.
Drug Interactions
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May interact with anticoagulants, diabetes drugs, diuretics, vaccines.
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Always disclose all medications and supplements to your healthcare provider.
Frequently Asked Questions (FAQs)
Q1: When will I feel relief?
A: Effects can start within minutes to hours.
Q2: How long is treatment?
A: Depends on condition; short courses are common.
Q3: Are injections painful?
A: Usually mild discomfort; local anesthetics may be used.
Q4: Can I self-administer?
A: Usually given by healthcare providers.
Q5: What if I miss a dose?
A: Follow your doctor’s instructions; do not double doses.
References
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MedlinePlus – Hydrocortisone Injection
https://medlineplus.gov/druginfo/meds/a682799.html -
Mayo Clinic – Hydrocortisone Injection
https://www.mayoclinic.org/drugs-supplements/hydrocortisone-intravenous-route/description/drg-20066823 -
American College of Rheumatology – Corticosteroid Use
https://www.rheumatology.org/I-Am-A/Patient-Caregiver/Treatments/Corticosteroids
This guide aims to provide comprehensive, reliable information about hydrocortisone injectable to support safe and effective clinical use. Always follow your healthcare provider’s guidance.
