Olopatadine (Nasal)

By /

PATANASE (Nasal) Olopatadine

Uses & Indications

PATANASE nasal spray, containing olopatadine, is an effective antihistamine for the treatment of allergic nasal symptoms. It is primarily indicated for:

  • Seasonal Allergic Rhinitis (SAR): Relief of sneezing, nasal itching, runny nose, and congestion triggered by seasonal allergens such as pollen.
  • Perennial Allergic Rhinitis (PAR): Management of year-round symptoms caused by allergens like dust mites, pet dander, or mold.

PATANASE is suitable for adults and children (≥6 years) who require a targeted nasal therapy, especially when oral antihistamines are insufficient or cause systemic side effects.

How It Works

PATANASE contains olopatadine hydrochloride, a selective H1 histamine receptor antagonist. Allergic rhinitis occurs when allergens trigger histamine release from mast cells in the nasal mucosa, resulting in symptoms such as itching, sneezing, and congestion.

Mechanism of action:

  • Histamine Blockade: Olopatadine binds to H1 receptors in the nasal passages, preventing histamine from causing typical allergic symptoms.
  • Mast Cell Stabilization: Reduces further release of histamine and inflammatory mediators.
  • Localized Effect: Intranasal administration ensures high local concentration with minimal systemic absorption, lowering the risk of drowsiness and other systemic side effects.

This dual action helps control both immediate and ongoing allergic responses.

Dosage and Administration

Formulation: PATANASE is supplied as a nasal spray containing olopatadine hydrochloride.

Recommended Dosage:

  • Adults and Children ≥12 years: 2 sprays in each nostril twice daily.
  • Children 6–11 years: 1 spray in each nostril twice daily.

Administration Instructions:

  1. Gently blow the nose to clear nasal passages.
  2. Shake the bottle gently before use.
  3. Tilt the head slightly forward and insert the nozzle into one nostril.
  4. Close the other nostril and spray while gently inhaling.
  5. Repeat in the other nostril.
  6. Rinse the nozzle with warm water after use.
  7. Avoid sneezing or blowing your nose immediately after administration to ensure absorption.

Adherence to the recommended dosing schedule ensures optimal relief of allergic symptoms.

Side Effects

PATANASE is generally well-tolerated. Most side effects are mild and temporary.

Common Side Effects:

  • Nasal irritation or burning
  • Headache
  • Unpleasant taste or smell
  • Sneezing immediately after application

Less Common / Rare Side Effects:

  • Nosebleeds (epistaxis)
  • Dryness or discomfort in nasal passages
  • Mild drowsiness in rare cases

If severe or persistent side effects occur, patients should contact their healthcare provider.

Warnings and Precautions

  • Allergy History: Avoid use if allergic to olopatadine or any components of the nasal spray.
  • Nasal Disorders: Use with caution in patients with nasal ulcers, infections, or recent nasal surgery.
  • Pregnancy and Breastfeeding: Safety data is limited; use only if benefits outweigh potential risks. Consult a healthcare provider.
  • Children: Use only as directed for children ≥6 years; safety and efficacy in younger children are not established.
  • Eye Contact: Avoid contact; rinse immediately if accidental exposure occurs.
  • Driving: Minimal sedation risk, but caution if drowsiness occurs.

Drug Interactions

PATANASE has minimal systemic absorption, making drug interactions rare. Considerations include:

  • Other Antihistamines: Concurrent use with additional H1 antihistamines is usually unnecessary and may increase side effects.
  • CNS Depressants: Very low risk of additive sedation due to minimal systemic absorption.
  • Other Nasal Medications: Use with care; space administration to reduce irritation.

Always inform your healthcare provider of all medications, including over-the-counter products.

FAQs

Q1: How quickly does PATANASE work?
A: Symptom relief may begin within 30 minutes, with optimal effect after consistent twice-daily use.

Q2: Can PATANASE be used long-term?
A: Yes, it is safe for ongoing use under medical supervision, with periodic evaluation of effectiveness and safety.

Q3: Can children under 6 use PATANASE?
A: Safety and efficacy have not been established for children under 6 years old.

Q4: Can PATANASE be used with other allergy treatments?
A: It can be used alongside certain non-antihistamine treatments, such as nasal corticosteroids. Combining with other H1-antihistamines is generally unnecessary.

Q5: What should I do if I miss a dose?
A: Administer the missed dose as soon as possible, then continue your regular dosing schedule. Do not double the dose.

References

  1. U.S. Food and Drug Administration (FDA) – PATANASE (Olopatadine Hydrochloride) Nasal Spray Prescribing Information
    https://www.accessdata.fda.gov
  2. Meltzer EO, et al. “Efficacy and safety of olopatadine nasal spray in the treatment of allergic rhinitis.” Ann Allergy Asthma Immunol. 2000;85(5):401–407.
  3. Simons FE, Simons KJ. “Olopatadine: pharmacology, clinical efficacy, and safety in allergic disorders.” Clin Ther. 2002;24(6):881–902.

Table of Contents

→ Index
Scroll to Top