glimepiride antidiabetic medication

Amaryl is the brand name of glimepiride, an antidiabetic medication.


What is glimepiride?

It is a medication that belongs to sulfonylurea category of antidiabetic medication.

It is metabolized in the liver and excreted from the body with urine and to a less extent in feces.

Indications of glimepiride

  • Glimepiride is indicated for the treatment of type 2 diabetes mellitus in order to adjust the level of the blood sugar.

When the blood glucose is controlled, the risk of the following diseases is lowered:

  • Heart diseases including ischemia and failure.
  • Vascular accidents of the brain namely stroke.
  • In addition, it reduces the long term organ complications such as kidney and liver impairment.

The patient should commit a healthy diet system as well as physical exercise in order to get the best control of the blood glucose.


Usually, the physician prescribes Glimepiride as once daily with the first or the main meal.

The starting dose is 1-2 mg per day, while the maximum dose shouldn’t exceed 8 mg per day.

If the patient forgot a dose of glimepiride, he should take it once he remembered except if the next dose is close.

If the patient took an overdose of the medication, he should visit the nearest poison center for the risk of having a serious low blood glucose level.

Side effect of metformin pills

  • Lowering of the sugar level, especially if the patient is taking insulin or another antidiabetic medication. Moreover, it can happen if the patient is an alcoholic.
  • Allergic response in the form of swellings, itching, rash, and difficult breathing in severe cases.
  • Sunburn upon exposure to sun rays, so the patient should use sunblocks.
  • Headache.
  • Nausea and abdominal distention.
  • Weakness and dizziness.
  • Awareness of fast heartbeats.
  • Abdominal and stomach pain.
  • Bleeding from the gums or bleeding in the stool and urine.
  • Swelling around the eyes which may extend to be all over the body.
  • Difficult swallowing.
  • Diarrhea.
  • Wheezes and chest tightness.

Interactions with metformin pills

If the patient is taking colesevelam in addition to glimepiride, he should take them 4 hours apart.

This is because the first medication leads to less absorption of glimepiridem.

Moreover, glimepiride has many interactions with other medications, for example, aspirin, chloramphenicol, sulfsalazine, levofloxacine, and aminolevulinic acid.


  • Allergy to sulfa medications.
  • Severe kidney or liver disease.
  • Heart diseases.
  • Pregnancy or lactation because it can lead to low blood sugar to the baby.
  • Diabetic ketoacidosis.
  • Type 1 diabetes mellitus.
  • Thyroid gland diseases.
  • Glucose-6-phosphate dehydrogenase deficiency.
  • Complicated diabetes during pregnancy.

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